2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-106650
    CMDA
    CMDA is a prodrug that can release cytotoxic molecules under the action of CPG2. CMDA can be used for cancer research.
    CMDA
  • HY-B2121R
    6-Methoxy-2-naphthoic acid (Standard)
    6-Methoxy-2-naphthoic acid (Standard) (6-MNA (Standard)) is the analytical standard of 6-Methoxy-2-naphthoic acid (HY-B2121). This product is intended for research and analytical applications. 6-Methoxy-2-naphthoic acid (6-MNA) is the active metabolite of Nabumetone (HY-B0559). 6-Methoxy-2-naphthoic acid is also an inhibitor of COX-1 and COX-2. 6-Methoxy-2-naphthoic acid can inhibit the synthesis of gastric mucosal prostaglandin E2. 6-Methoxy-2-naphthoic acid can be used in the research of inflammation and pain-related diseases. In addition, 6-Methoxy-2-naphthoic acid is an impurity in Naproxen (HY-15030) and can also be used in the synthesis of other active compounds.
    6-Methoxy-2-naphthoic acid (Standard)
  • HY-W699907
    Pantoprazole sulfide-d8
    Pantoprazole sulfide-d8 is the deuterium labeled Pantoprazole sulfide (HY-W016033). Pantoprazole sulfide is a metabolite of Pantoprazole (HY-17507), which is a proton-pump inhibitor.
    Pantoprazole sulfide-d<sub>8</sub>
  • HY-135359R
    RP 48497 (Standard)
    Adenosine 5'-monophosphate (disodium) (Standard) is the analytical standard of Adenosine 5'-monophosphate (disodium). This product is intended for research and analytical applications. Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes.
    RP 48497 (Standard)
  • HY-157690
    19(S),20(R)-EDP
    19(S),20(R)-EDP is an epoxidized metabolite of docosahexaenoic acid (HY-B2167).
    19(S),20(R)-EDP
  • HY-142122R
    Imipramine N-oxide (Standard)
    Imipramine N-oxide (Standard) is the analytical standard of Imipramine N-oxide. This product is intended for research and analytical applications. Imipramine N-oxide is the metabolite of Imipramine. Imipramine is a tertiary amine tricyclic antidepressant[1][2].
    Imipramine N-oxide (Standard)
  • HY-17528R
    Cyhalofop (Standard)
    Cyhalofop (Standard) is the analytical standard of Cyhalofop. This product is intended for research and analytical applications. Cyhalofop (Cyhalofop acid), the primary metabolite of Cyhalofop-butyl (HY-B0861) in susceptible grasses, is the herbicidally active metabolite. Cyhalofop-butyl is an aryloxyphenoxypropionate post-emergence herbicide widely used around the world in agriculture.
    Cyhalofop (Standard)
  • HY-W770677
    9-Carboxymethoxymethylguanine-13C2,15N
    9-Carboxymethoxymethylguanine-13C2,15N is the 13C- and 15N-labeled 9-Carboxymethoxymethylguanine (HY-137181). 9-Carboxymethoxymethylguanine is the main metabolite of Aciclovir. Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent.
    9-Carboxymethoxymethylguanine-<sup>13</sup>C<sub>2</sub>,<sup>15</sup>N
  • HY-W724397
    3-Phenoxybenzoic acid-d9
    3-Phenoxybenzoic acid-d9 (3-PBA-d9) is the deuterium labeled 3-Phenoxybenzoic acid (HY-W014225). 3-Phenoxybenzoic acid is the metabolite of pyrethroid insecticides. 3-Phenoxybenzoic acid induces immunotoxicity and oxidative stress, and inhibits the phagocytic ability of macrophages.
    3-Phenoxybenzoic acid-d<sub>9</sub>
  • HY-W178868S
    Lodoxamide impurity 1-d5
    Lodoxamide impurity 1-d5 is deuterium labeled n-Ethyl-2-hydroxyacetamide.
    Lodoxamide impurity 1-d<sub>5</sub>
  • HY-13056R
    SMND-309 (Standard)
    Dimepiperate (Standard) is the analytical standard of Dimepiperate. This product is intended for research and analytical applications. Dimepiperate (MY 93) is a thiocarbamate (TC) pesticide. Dimepiperate has potential off-targets effect for the inhibition of ABHD6.
    SMND-309 (Standard)
  • HY-131270
    Febuxostat impurity 8
    Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat impurity 8
  • HY-114656
    Dihydro-PGF1α
    Dihydro-PGF1α is a potential metabolite of PGF1α.
    Dihydro-PGF1α
  • HY-172832
    (±)7(8)-DiHDTE
    (±)7(8)-DiHDTE is a metabolite of Docosapentaenoic acid (22n-3) (HY-113159). Docosapentaenoic acid (22n-3) is a component of phospholipids. Docosapentaenoic acid 22n-3 has inhibitory activity against α-amylase and α-glucosidase with IC50s of 17 and 22 μg/mL, respectively. Docosapentaenoic acid 22n-3 increases cell vitality. Docosapentaenoic acid 22n-3 has a weak anti-inflammatory effect.
    (±)7(8)-DiHDTE
  • HY-Z0081
    2S,4R-Sacubitril
    2S,4R-Sacubitril is the impurity of Sacubitril. Sacubitril is approved by the Food and agent Administration for use in combination with valsartan for the treatment of patients with heart failure.
    2S,4R-Sacubitril
  • HY-143992S
    Maytansinoid DM4 impurity 2-d6
    Maytansinoid DM4 impurity 2-d6 is the deuterium labeled Maytansinoid DM4 impurity 2.
    Maytansinoid DM4 impurity 2-d<sub>6</sub>
  • HY-148377
    Abiraterone sulfate N-oxide
    Abiraterone sulfate N-oxide is a carboxylic acid. Abiraterone sulfate N-oxide also is a major metabolite of Abiraterone (HY-70013). Abiraterone sulfate N-oxide can be used for the research of prostate cancer.
    Abiraterone sulfate N-oxide
  • HY-W013272R
    Hydroxyflutamide (Standard)
    Hydroxyflutamide (Standard) (HFT (Standard)) is the analytical standard of Hydroxyflutamide (HY-W013272). This product is intended for research and analytical applications. Hydroxyflutamide (HFT) is the active metabolite of Flutamide (HY-B0022) and exhibits oral activity. Hydroxyflutamide is a potent androgen receptor antagonist with an IC50 of 700 nM. Hydroxyflutamide can affect embryonic development and reproductive tract development in mice. Additionally, Hydroxyflutamide can enhance the efficacy of Bacillus Calmette-Guérin (BCG) to better inhibit the progression of bladder cancer. Hydroxyflutamide can be used in research related to tumors and reproductive diseases.
    Hydroxyflutamide (Standard)
  • HY-B0802AR
    Terbutaline (Standard)
    Benactyzine hydrochloride (Standard) is the analytical standard of Benactyzine hydrochloride. This product is intended for research and analytical applications. Benactyzine hydrochloride is a competitive BChE inhibitor with a Ki of 0.01 mM. Benactyzine hydrochloride is an anticholinergic drug. Benactyzine hydrochloride has the potential for organophosphate poisoning research.
    Terbutaline (Standard)
  • HY-N17811
    Vincristine metabolite-1
    Vincristine metabolite-1 (Compound M1) is the major metabolite of Vincristine (HY-N0488A) by CYP3A4 and CYP3A5.
    Vincristine metabolite-1
Cat. No. Product Name / Synonyms Application Reactivity